Antiepileptic drugs: newer targets and new drugs
نویسندگان
چکیده
منابع مشابه
Newer antiepileptic drugs
Epilepsy is a very common neurological disorder with high prevalence and incidence. Several conventional antiepileptic drugs are being used for the treatment of various types of epilepsies. Over the last two decades, there has been a rapid expansion in the number and types of available antiepileptic drugs (AED). Newer AEDs are now available for the treatment of various forms of epilepsies. Lamo...
متن کاملAstrocytes as new targets for antiepileptic drugs
Epilepsy is a disorder of the brain characterised by un-provoked, recurrent seizures and affects about 1% of the population worldwide. A deeper understanding of the cellular basis of the epilepsies would be essential for the identification of novel targets for therapeutic intervention. Since neuronal hyperexcitation and hypersynchronization are hallmarks of epilepsy, the search for new antiepil...
متن کاملAre newer antiepileptic drugs associated with improved safety in pregnancy compared to older antiepileptic drugs?
Commentary As a group, antiepileptic drugs (AEDs) are associated with an increased risk of major congenital malformations (MCMs) (1). Older AEDs are the best studied. Valproate (VPA) is consistently associated with an increased risk of MCMs including an increased risk of spina bifida (2). Phenobarbital (PB) exposure increases the risk of MCMs, including oral clefts (3). Although not consistent ...
متن کاملNew antiepileptic drugs – an
The last ten years of the 20th century is called in neuroscience “decade of the brain”. This period has brought many new antiepileptic drugs (AEDs) to the practising physician. New AEDs include: vigabatrin, lamotrigine, topiramate, tiagabine, gabapentin, oxcarbazepine, levetiracetam and zonisamide (not registered in Poland). The development of these drugs was under the current epilepsy theory (...
متن کاملNew antiepileptic drugs and women
Since 1990, sixteen new antiepileptic drugs (AEDs) have been introduced. Most of these new AEDs have only been insufficiently studied with respect to women-specific aspects such as endogenous sex hormones, hormonal contraception, pregnancy, breastfeeding, or menopause. This is of concern because it has been shown for some of the new AEDs that these factors may have a clinically significant impa...
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ژورنال
عنوان ژورنال: International Journal of Basic and Clinical Pharmacology
سال: 2016
ISSN: 2319-2003
DOI: 10.18203/2319-2003.ijbcp20161495